Pharmacology of Gastrointestinal and Hepatobiliary Disorders Essay
The main symptoms common in patients with gastrointestinal conditions are mostly non-specific. It is vital for the care providers to do an extensive assessment to get to know the cause of the presentations (Caplan et al., 2017). The process scan be complicated by the fact that gastrointestinal manifestations could occur in the diseases’ backgrounds involving other different systems. In this case, the patient has symptoms like diarrhea, vomiting and nausea and they are non-specific to the gastrointestinal symptoms (Caplan et al., 2017). The patient has a history of drug and substance abuse and suspected hepatitis C. Hepatitis C can be placed as a diagnosis after the polymerase chain reaction (PCR) is done to identify the HCV RNA in the serum. Pharmacology of Gastrointestinal and Hepatobiliary Disorders Essay
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Prednisone could be an excellent medication for the gastrointestinal tract. It elevates the production of gastric acid in one month. The corticosteroids adversely affect the effect the gastric mucosa has which increases the risk of the patient getting gastric ulcers or gastritis (Elliott et al., 2018). It entails inhibiting phospholipid conversion into arachidonic acid to stop production of prostaglandin.
Several principles can be applied to minimize the side effects a patient experience from oral glucocorticoids. The best is a reassessment on how a patient uses it and the necessity for him to use them (Elliott et al., 2018). It also entails reducing the duration or the use and providing mucosal protective agents like sulcrafate and bismuth subsalicylate (Caplan et al., 2017). The agents are critical since they coat the areas of erosion and ulcers to prevent them from being damaged by the gastric acid. Patient information is also critical since it helps in giving the patents with information on the kind of diet he can use to get better and the compliance in taking medications. Pharmacology of Gastrointestinal and Hepatobiliary Disorders Essay
References
Caplan, A., Fett, N., Rosenbach, M., Werth, V. P., & Micheletti, R. G. (2017). Prevention and management of glucocorticoid-induced side effects: a comprehensive review: a review of glucocorticoid pharmacology and bone health. Journal of the American Academy of Dermatology, 76(1), 1-9.
Elliot, S. Y., SS, Y. P., & Venkatesan, T. (2018). Migraine, cyclic vomiting syndrome, and other gastrointestinal disorders. Current treatment options in gastroenterology, 16(4), 511-527.
Pharmacology Assignment
Write a 1-page paper about the case study that addresses the following:
- Explain your diagnosis for the patient, including your rationale for the diagnosis.
- Describe an appropriate drug therapy plan based on the patient’s history, diagnosis, and drugs currently prescribed.
- Justify why you would recommend this drug therapy plan for this patient. Be specific and provide examples. Pharmacology of Gastrointestinal and Hepatobiliary Disorders Essay
Case Study
DC is a 46-year-old female who presents with a 24-hour history of RUQ pain. She states the pain started about 1 hour after a large dinner she had with her family. She has had nausea and on instance of vomiting before presentation.
| PMH: | Vitals: |
| HTN | Temp: 98.8oF |
| Type II DM | Wt: 202 lbs |
| Gout | Ht: 5’8” |
| DVT – Caused by oral BCPs | BP: 136/82 |
| HR: 82 bpm |
| Current Medications: |
Notable Labs: |
| Lisinopril 10 mg daily | WBC: 13,000/mm3 |
| HCTZ 25 mg daily | Total bilirubin: 0.8 mg/dL |
| Allopurinol 100 mg daily | Direct bilirubin: 0.6 mg/dL |
| Multivitamin daily | Alk Phos: 100 U/L |
| AST: 45 U/L | |
| ALT: 30 U/L |
Allergies:
- Latex
- Codeine
- Amoxicillin
PE:
- Eyes: EOMI
- HENT: Normal
- GI:bNondistended, minimal tenderness
- Skin:bWarm and dry
- Neuro: Alert and Oriented
- Psych:bAppropriate mood